Publications
![Discovery of 6-substituted thieno[2,3-d]pyrimidine analogs as dual inhibitors of glycinamide ribonucleotide formyltransferase and 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase in de novo purine nucleotide biosynthesis in folate receptor expressing human tumors](https://dann.lab.indiana.edu/wp-content/plugins/ezpublications//assets/images/default-pic.jpg)
Discovery of 6-substituted thieno[2,3-d]pyrimidine analogs as dual inhibitors of glycinamide ribonucleotide formyltransferase and 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase in de novo purine nucleotide biosynthesis in folate receptor expressing human tumors
Wallace-Povirk A, Tong N, Wong-Roushar J, O'Connor C, Zhou X, Hou Z, Bao X, Garcia GE, Li J, Kim S, Dann CE, Matherly LH, and Gangjee A. Bioorganic & Medicinal Chemistry, 2021 May 1; 37: 116093: 0968-0896. doi: 10.1016/j.bmc.2021.116093. Epub: 2021 Feb 26.
Novel Pyrrolo[3,2-d]pyrimidine Compounds Target Mitochondrial and Cytosolic One-carbon Metabolism with Broad-spectrum Antitumor Efficacy.
Mol Cancer Ther. 2019 Oct;18(10):1787-1799. doi: 10.1158/1535-7163.MCT-19-0037. Epub 2019 Jul 9.
Distinguishing Sulfotyrosine Containing Peptides from their Phosphotyrosine Counterparts Using Mass Spectrometry.
J Am Soc Mass Spectrom. 2018 Mar;29(3):455-462. doi: 10.1007/s13361-017-1854-1. Epub 2018 Jan 8.
The C-Terminal Region of Bacillus subtilis SwrA Is Required for Activity and Adaptor-Dependent LonA Proteolysis.
J Bacteriol. 2018 Feb 23;200(6):e00659-17. doi: 10.1128/JB.00659-17. Print 2018 Mar 15.
MotI (DgrA) acts as a molecular clutch on the flagellar stator protein MotA in Bacillus subtilis.
Proc Natl Acad Sci U S A. 2017 Dec 19;114(51):13537-13542. doi: 10.1073/pnas.1716231114. Epub 2017 Dec 1.
Correction to Structural and Enzymatic Analysis of Tumor-Targeted Antifolates That Inhibit Glycinamide Ribonucleotide Formyltransferase.
Biochemistry. 2017 Feb 21;56(7):1025. doi: 10.1021/acs.biochem.7b00092. Epub 2017 Feb 10.
Tumor Targeting with Novel 6-Substituted Pyrrolo [2,3-d] Pyrimidine Antifolates with Heteroatom Bridge Substitutions via Cellular Uptake by Folate Receptor α and the Proton-Coupled Folate Transporter and Inhibition of de Novo Purine Nucleotide Biosynthesis.
J Med Chem. 2016 Sep 8;59(17):7856-76. doi: 10.1021/acs.jmedchem.6b00594. Epub 2016 Aug 26.
Structural and Enzymatic Analysis of Tumor-Targeted Antifolates That Inhibit Glycinamide Ribonucleotide Formyltransferase.
Biochemistry. 2016 Aug 16;55(32):4574-82. Epub 2016 Aug 3.
The C-Terminal Region of Bacillus subtilis SwrA Is Required for Activity and Adaptor-Dependent LonA Proteolysis.
Hughes AC, Subramanian S, Dann CE 3rd, Kearns DB. The C-Terminal Region of Bacillus subtilis SwrA Is Required for Activity and Adaptor-Dependent LonA Proteolysis. J Bacteriol. 2018 Feb 23;200(6):e00659-17. Print 2018 Mar 15.
MotI (DgrA) acts as a molecular clutch on the flagellar stator protein MotA in Bacillus subtilis.
Subramanian S, Gao X, Dann CE 3rd, Kearns DB. MotI (DgrA) acts as a molecular clutch on the flagellar stator protein MotA in Bacillus subtilis. Proc Natl Acad Sci U S A. 2017 Dec 19;114(51):13537-13542. Epub 2017 Dec 1.
Correction to Structural and Enzymatic Analysis of Tumor-Targeted Antifolates That Inhibit Glycinamide Ribonucleotide Formyltransferase.
Biochemistry. 2017 Feb 21;56(7):1025. Epub 2017 Feb 10.
Tumor Targeting with Novel 6-Substituted Pyrrolo [2,3-d] Pyrimidine Antifolates with Heteroatom Bridge Substitutions via Cellular Uptake by Folate Receptor α and the Proton-Coupled Folate Transporter and Inhibition of de Novo Purine Nucleotide Biosynthesis.
Golani LK, Wallace-Povirk A, Deis SM, Wong J, Ke J, Gu X, Raghavan S, Wilson MR, Li X, Polin L, de Waal PW, White K, Kushner J, O'Connor C, Hou Z, Xu HE, Melcher K, Dann CE 3rd, Matherly LH, Gangjee A.Tumor Targeting with Novel 6-Substituted Pyrrolo [2,3-d] Pyrimidine Antifolates with Heteroatom Bridge Substitutions via Cellular Uptake by Folate Receptor α and the Proton-Coupled Folate Transporter and Inhibition of de Novo Purine Nucleotide Biosynthesis. J Med Chem. 2016 Sep 8;59(17):7856-76. Epub 2016 Aug 26.
Structural and Enzymatic Analysis of Tumor-Targeted Antifolates That Inhibit Glycinamide Ribonucleotide Formyltransferase.
Deis SM, Doshi A, Hou Z, Matherly LH, Gangjee A, Dann CE 3rd. Structural and Enzymatic Analysis of Tumor-Targeted Antifolates That Inhibit Glycinamide Ribonucleotide Formyltransferase. Biochemistry. 2016 Aug 16;55(32):4574-82. Epub 2016 Aug 3.
6-Substituted Pyrrolo[2,3-d]pyrimidine Thienoyl Regioisomers as Targeted Antifolates for Folate Receptor α and the Proton-Coupled Folate Transporter in Human Tumors
Engineered Bacillus subtilis strains allow rapid characterization of heterologous diguanylate cyclases and phosphodiesterases
Gao X, Dong X, Subramanian S, Matthews PM, Cooper CA, Kearns DB, Dann CE 3rd. Engineered Bacillus subtilis strains allow rapid characterization of heterologous diguanylate cyclases and phosphodiesterases. Appl Environ Microbiol. 2014 Oct; 80(19), 6167-74. Epub 1 August 2014.
Cu(I)-mediated allosteric switching in a copper-sensing operon repressor (CsoR)
Chang F-MJ, Coyne HJ, Cubillas-Ramirez CA, Fleischmann PV, Fang X, Ma Z, Ma D, Helmann JD, García-de los Santos A, Wang Y-X, Dann CE 3rd, Giedroc DP. Cu(I)-mediated allosteric switching in a copper-sensing operon repressor (CsoR). J Biol Chem. 2014 Jul 4; 289(27):19204-19217. Epub 2014 May 15 doi:10.1074/jbc.M114.552380.
Redox and light control the heme-sensing activity of AppA
Yin L, Dragnea V, Feldman G, Hammad LA, Karty JA, Dann CE 3rd, Bauer CE. Redox and light control the heme-sensing activity of AppA. MBio. 2013 Aug 27;4(5):e00563-13. doi: 10.1128/mBio.00563-13. PubMed PMID: 23982072; PubMed Central PMCID: PMC3760249.
Functional Characterization of Core Components of the Bacillus subtilis Cyclic-Di-GMP Signaling Pathway
Gao X, Mukherjee S, Matthews PM, Hammad LA, Kearns DB, Dann CE 3rd. Functional Characterization of Core Components of the Bacillus subtilis Cyclic-Di-GMP Signaling Pathway. J Bacteriol. 2013 Nov;195(21):4782-92. doi: 10.1128/JB.00373-13. Epub 2013 Jul 26. PubMed PMID: 23893111. Highlighted in journal with an article written by Rita Tamayo. The characterization of a cyclic-di-GMP (c-di-GMP) pathway leads to a new tool for studying c-di-GMP metabolic genes. J Bacteriol. 2013 Nov;195(21):4779-81. doi: 10.1128/JB.00925-13. Epub 2013 Aug 16. PubMed PMID: 23955008; PubMed Central PMCID: PMC3807499.
Structures of human folate receptors reveal biological trafficking states and diversity in folate and antifolate recognition
Wibowo AS, Singh M, Reeder KM, Carter JJ, Kovach AR, Meng W, Ratnam M, Zhang F, Dann CE 3rd. Structures of human folate receptors reveal biological trafficking states and diversity in folate and antifolate recognition. Proc Natl Acad Sci U S A. 2013 Sep 17;110(38):15180-8. doi: 10.1073/pnas.1308827110. Epub 2013 Aug 9. PubMed PMID: 23934049; PubMed Central PMCID: PMC3780903. Highlighted by National Institutes of Health Director Francis Collins on the NIH Director’s blog.
A new structural paradigm in copper resistance in Streptococcus pneumoniae
Fu Y, Tsui HC, Bruce KE, Sham LT, Higgins KA, Lisher JP, Kazmierczak KM, Maroney MJ, Dann CE 3rd, Winkler ME, Giedroc DP "A new structural paradigm in copper resistance in Streptococcus pneumoniae." Nat Chem Biol. 2013 Mar; 9(3):177-83. doi: 10.1038/nchembio.1168. Epub 2013 Jan 27.
Allosteric inhibition of a zinc-sensing transcriptional repressor: Insights into the arsenic repressor (ArsR) family
Campanello GC, Ma Z, Grossoehme NE, Guerra AJ, Ward BP, Dimarchi RD, Ye Y, Dann CE 3rd, Giedroc DP. "Allosteric inhibition of a zinc-sensing transcriptional repressor: Insights into the arsenic repressor (ArsR) family." J Mol Biol. 2013 Apr 12;425(7):1143-57. doi: 10.1016/j.jmb.2013.01.018. Epub 2013 Jan 23.
Oxidative lipid modification of nicastrin enhances amyloidogenic γ-secretase activity in Alzheimer's disease
Gwon AR, Park JS, Arumugam TV, Kwon YK, Chan SL, Kim SH, Baik SH, Yang S, Yun YK, Choi Y, Kim S, Tang SC, Hyun DH, Cheng A, Dann CE 3rd, Bernier M, Lee J, Markesbery WR, Mattson MP, Jo DG. "Oxidative lipid modification of nicastrin enhances amyloidogenic γ-secretase activity in Alzheimer's disease." Aging Cell. 2012 Aug;11(4):559-68. doi: 10.1111/j.1474-9726.2012.00817. Epub 2012 Apr 9.
Crystal Structure of the Zinc-Dependent MarR Family Transcriptional Regulator AdcR in the Zn(II)-Bound State
Guerra AJ, Dann CE 3rd, Giedroc DP. "Crystal Structure of the Zinc-Dependent MarR Family Transcriptional Regulator AdcR in the Zn(II)-Bound State." J Amer Chem Soc. 2011 Dec 14;133(49):19614-7. doi: 10.1021/ja2080532. Epub 2011 Nov 21.
RNA Structure: Riboswitch Strikes a Chord
Dann CE 3rd. "RNA Structure: Riboswitch Strikes a Chord." Nat Chem Biol.2011 Sep 19;7(10):660-1. doi: 10.1038/nchembio.672
Conformational changes in the hepatitis B virus core protein are consistent with a role for allostery in virus assembly
Packianathan C, Katen SP, Dann CE 3rd, Zlotnick A. "Conformational changes in the hepatitis B virus core protein are consistent with a role for allostery in virus assembly." J Virol. 2010 Feb;84(3):1607-15. doi: 10.1128/JVI.02033-09. Epub 2009 Nov 25
Coronavirus N protein N-terminal domain (NTD) specifically binds the transcriptional regulatory sequence (TRS) and melts TRS-cTRS RNA duplexes
Grossoehme NE, Li L, Keane SC, Liu P, Dann CE 3rd, Leibowitz JL, Giedroc DP. "Coronavirus N protein N-terminal domain (NTD) specifically binds the transcriptional regulatory sequence (TRS) and melts TRS-cTRS RNA duplexes." J Mol Biol. 2009 Dec 4;394(3):544-57. doi: 10.1016/j.jmb.2009.09.040. Epub 2009 Sep 24.
Structure and Mechanism of a Metal-Sensing Regulatory RNA
Dann CE 3rd, Wakeman CA, Sieling CL, Baker SC, Irnov I, Winkler WC. "Structure and Mechanism of a Metal-Sensing Regulatory RNA." Cell. 2007 Sep 7;130(5):878-92.
Structural Features of Metabolite-Sensing Riboswitches
Wakeman CA, Winkler WC, Dann CE 3rd. "Structural Features of Metabolite-Sensing Riboswitches." Trends Biochem Sci. 2007 Sep;32(9):415-24. Epub 2007 Aug 30. Review.
RNA allostery glimpsed
Dann CE 3rd, Winkler WC. "RNA allostery glimpsed." Nat Struct Mol Biol. 2006 Jul;13(7):569-71. (News and Views).
Dioxygenases as O2-dependent regulators of the hypoxic response pathway
Dann CE 3rd, Bruick RK. "Dioxygenases as O2-dependent regulators of the hypoxic response pathway." Biochem Biophys Res Commun.2005 Dec 9;338(1):639-47. Epub 2005 Aug 26. Review.
Nicastrin functions as a gamma-secretase-substrate receptor
Shah S, Lee SF, Tabuchi K, Hao YH, Yu C, LaPlant Q, Ball H, Dann CE 3rd, Sudhof T, Yu G. "Nicastrin functions as a gamma-secretase-substrate receptor." Cell. 2005 Aug 12;122(3):435-47.
Crystal structure of Caenorhabditis elegans HER-1 and characterization of the interaction between HER-1 and TRA 2A
Hamaoka B, Dann CE 3rd, Geisbrecht BV, Leahy DJ. "Crystal structure of Caenorhabditis elegans HER-1 and characterization of the interaction between HER-1 and TRA 2A." Proc Natl Acad Sci U S A. 2004 Aug 10;101(32):11673-8. Epub 2004 Aug 2.
Structure of factor-inhibiting hypoxia-inducible factor 1: An asparaginyl hydroxylase involved in the hypoxic response pathway
Dann CE 3rd, Bruick RK, Deisenhofer J. "Structure of factor-inhibiting hypoxia-inducible factor 1: An asparaginyl hydroxylase involved in the hypoxic response pathway." Proc Natl Acad Sci U S A. 2002 Nov 26;99(24):15351-6. Epub 2002 Nov 13.
Insights into Wnt binding and signalling from the structures of two Frizzled cysteine-rich domains
Dann CE 3rd, Hsieh JC, Rattner A, Sharma D, Nathans J, Leahy DJ. "Insights into Wnt binding and signalling from the structures of two Frizzled cysteine-rich domains." Nature. 2001 Jul 5;412(6842):86-90.
Ribonucleases, Part A: Functional Roles and Mechanisms of Action. 'RNA lariat debranching enzyme
Ooi SL, Dann C 3rd, Nam K, Leahy DJ, Dahma MJ, Boeke JD. "Ribonucleases, Part A: Functional Roles and Mechanisms of Action. 'RNA lariat debranching enzyme.'" Methods in Enzymology 2001;341.
A mammalian expression vector for expression and purification of secreted proteins for structural studies
Leahy DJ, Dann CE 3rd, Longo P, Perman B, Ramyar K "A mammalian expression vector for expression and purification of secreted proteins for structural studies." Protein Expr Purif. 2000 Dec;20(3):500-6.
Separation of enantiomers using vancomycin in a countercurrent process by suppression of electroosmosis
Ward TJ, Dann CE 3rd, Brown AP. "Separation of enantiomers using vancomycin in a countercurrent process by suppression of electroosmosis." Chirality. 1996 Jan;8(1):77-83. doi: 10.1002/(SICI)1520-636X(1996)8:1<77::AID-CHIR13>3.0.CO;2-P
Enantiomeric resolution using the macrocyclic antibiotics rifamycin B and rifamycin SV as chiral selectors for capillary electrophoresis
Ward TJ, Dann CE 3rd, Blaylock A. "Enantiomeric resolution using the macrocyclic antibiotics rifamycin B and rifamycin SV as chiral selectors for capillary electrophoresis." J Chromatogr A. 1995 Nov 3;715(2):337-44.
Enantiomeric Resolution Using the Macrocyclic Antibiotics Rifamycin-B and Rifamycin-Sv as Chiral Selectors for Capillary Electrophoresis T. J. Ward, C. Dann and A. Blaylock Journal of Chromatography A 1995 Vol. 715 Issue 2 Pages 337-344 Accession Number: WOS:A1995TF09400016 DOI: Doi 10.1016/0021-9673(95)00608-P
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