Deblina finished her M.S. degree at the beginning of the Fall 2011 semester and was promptly hired in October 2011 as an Associate Scientist at Cook Pharmica here in Bloomington. Though details of her research projects are not available, she will certainly be using her skills as a protein biochemist to use developing expression or production of a biomolecule for therapeutic use. We are proud of you Deblina! Congratulations! – CD3
Hello, My name is Deblina De Ghosh. I am from India. I was born in a small beautiful town named Jhargram where my parents still live. I have finished my B.Sc. in Chemistry from Calcutta University and M.Sc in Organic Chemistry from G.G. University in India.
I joined Dann group in November 2008. The main objective of my research project is the structural and biochemical analysis of preQ1 riboswitch. This preQ1 riboswich contains the smallest known natural aptamer domain, which specifically binds to preQ1 to regulate gene expression in cis. PreQ1 is the biosynthetic precursor of a hypermodified nucleoside named queuosine (Q), which is important for translational fidelity. Biochemical binding assays as well as engineering studies will be done to study the specificity and affinity of this riboswitch towards its natural ligand as well as additional small molecule effectors that may serve as antibiotic drugs. These RNAs could also be used as inducible switches or sensors. Thus unraveling the structure and biology of this riboswitch could greatly benefit our understanding of gene regulation and human disease.
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