Hello, my name is Mirage Singh. I am from India and completed my Ph.D. in life sciences from Jawaharlal Nehru University, New Delhi, India.
I joined the Dann group as a postdoctoral fellow in July 2011. Currently, my research project is structural studies on the human folate receptors. Humans have three hFRs, i.e., FRα, FRβ and FRγ. FRα is present on the basolateral surface of normal cells while it is overexpressed on all surfaces of cancerous cells to meet the folate demand in tumors. This receptor has been characterized as a potential antitumor target. My research goal is to elucidate the three dimensional structure of this receptor. This structural information will be utilized to develop specific inhibitors against FRα. I also aim to determine the structure of FRγ, which is a secreted form of folate receptor bindig domain and shares high sequence similarities with FRα and FRβ. This structural study on FRγ will help to understand the structure function relationship of folate receptors in more detail.
I aim to establish myself as an independent researcher and contribute to science. I also have interest in teaching and wish to join academia for teaching and research in future.
The College of Arts